Curriculum Vitae of Prof. Dr. Rainer U. Pliquett

















Birth date: 09/09/70 in Leipzig, Germany

Status: married, 1 child

Nationality: German

Health status: excellent, no handicap

Languages: German (native), English (fluently), French (fluently), Russian (intermediate level), Hungarian (basic knowledge)

Email: rpliquett(at)endothel.de



Affiliations

- Department of Nephrology and Hypertensiology, Elblandklinikum Riesa, Weinbergstr. 8, 01589 Riesa

- Martin-Luther University Halle-Wittenberg, Department of Internal Medicine II, Head: Prof. Dr. M. Girndt (Research, Teaching activities, not for profit)

- Institute for Applied Information Technologies in Medicine and Outpatient Practice of Internal Medicine /Family Medicine in Saxony (not for profit)





Work experience

Jul 2024 – currently: Chairman of Department of Nephrology and Hypertensiology, Elblandklinikum Riesa, Weinbergstr. 8, 01589 Riesa

Sep 2022 – Jun 2024: Family Physician with focus on diabetology and prevention of end-stage renal disease in MVZ Gemeinschaftslabor Cottbus, 03050 Cottbus, Uhlandstr. 53 (between Jan 2023 – June 2023: in part time, otherwise: in full time)



Jan 2023 – Jun 2023: Head of hemodialysis and outpatient nephrology clinic of Kuratorium of Heimdialyse (KFH) at 06847 Dessau- Roßlau, Kastanienhof 1, Germany (in full time)



Jun 2018 –: Sep 2022: Head of Department of Nephrology, Diabetology, Department size: 34 beds, 12 Hemodialysis slots, 6 automatic peritoneal dialysis slots, 2 plasmapheresis slots,

- Sep 2019 – Dec 2019: Head of Department of Geriatry (temporary position during transition period), Department size: 46 beds and outpatient clinic („Tagesklinik“)

- 2021 – 2022: weekly Pediatry - Diabetology joint grand rounds

- 2021 - 2022 weekly joint Gyn-OB – Diabetology outpatient clinic

- 2020 – 2022 start of a new of its kind, in-hospital class for Patient-Empowerment of Obese Patients



Sep 2010May 2018: Attending Physician (Nephrology, Diabetology, Transplantation Medicine) at Department of Internal Medicine 2, University Hospital Halle, Martin-Luther- Universität Halle-Wittenberg, Head: Prof. Dr. Matthias Girndt,

- Sabbatical for Diabetology training (from Jun 2015 - Aug 2015 in the Academic Teaching Hospital St. Elisabeth”, 1st Medical Department, Head: Prof. Dr. Gerhard. H. Scholz)



23rd March.2009 – Aug 2010: Staff Nephrologist at outpatient nephrology clinic (Kuratorium für Heimdialyse, KFH) at St. Georg Hospital, 04129 Leipzig, Delitzscher Str. 141, Head: Prof. Dr. Joachim H. Beige



Apr 2008 – Mar 2009: Staff Nephrologist at Department of Nephrology, Goethe University, Frankfurt a.M., Head: Prof. Dr. Helmut Geiger



Jul 2006 – Mar 2008 Staff Physician, Nephrologist in-training, Department of Nephrology, Goethe University, Frankfurt a.M., Head: Prof. Dr. Helmut Geiger

- Principle Investigator in investigator-initiiated randomized clinical study: “Oral Supplemental Nutrition in Patients with end-stage renal disease with or without HIV Comorbidity“ (clinicaltrials.gov ID: NCT00687050)

- Sub-Investigator in VIPP-Study (Randomized multicenter trial comparing Valganciclovir CMV prophylaxis versus pre-emptive therapy after renal transplantation), MIRACLE Studie (A Study Of Once-Monthly Intravenous Mircera in Hemodialysis Patients With Chronic Renal Anemia)



Apr 2006 – Jun 2006: Internal-Medicine training: Gastroenterology at University Hospital Leipzig, Department of Gastroenterology, Head: Prof. Dr. Joachim Mössner



Oct 2005 – Mar 2006: Internal-Medicine training: Emergency Medicine at University Hospital Leipzig, Emergency Department, Head: Prof. Dr. Christoph Bärwald



Apr 2005 – Sep 2005: Internal-Medicine training: Endokrinology / Diabetology at University Hospital Leipzig, Department of Endocrinology/Diabetology/Renal Disesases, Head: Prof. Michael Stumvoll



Jan 2005 – Mar 2005: Internal-Medicine training: Oncology/Hematology at University Hospital Leipzig, Department of Oncology/Hematology, Head: Prof. Dr. Dietger Niederwieser



Sep 2004 – Dec 2004: Internal-Medicine training: Endokrinology / Diabetology at University Hospital Leipzig, Department of Endocrinology/Diabetology/Renal Disesases, Head: Prof. Dr. Ralf Paschke



Nov 2003 – Aug 2004: Internal-Medicine training: Nephrology at University Hospital Leipzig, Department of Endocrinology/Diabetology/Renal Disesases, Head: Prof. Dr. Ralf Paschke



Apr 2003 – Oct 2003: Sabbatical in the Department of Molecular Biochemistry, University of Leipzig, Head: Prof. Dr. Torsten Schöneberg



Jul 2002 – Mar 2003: Internal-Medicine training: Nephrology at University Hospital Leipzig, Department of Endocrinology/Diabetology/Renal Disesases, Head: Prof. Dr. Ralf Paschke



Dec 2001 – Jun 2002 Internal-Medicine training: Cardiology – Intensive-Care Unit (6 months), Heart Centre Leipzig, Head: Prof. Dr. Gerhard Schuler



Nov 1999 - Nov 2001: Post-doctoral Fellowship in Physiology

- 1st Topic: Neuroendocrinologic Regulation in chronic heart failure: Role of exercise training.

- 2nd Topic: Role of statin therapy in Chronic Heart Failure“), University of Nebraska, Medical Center, Department of Integrative Physiology, Omaha, NE, USA. Head: Prof. Dr. Irving H. Zucker.



Apr 1997 - Oct 1999: Internal-Medicine training: Cardiology – Intensive-Care Unit (6 months), Heart Centre Leipzig, Head: Prof. Dr. Gerhard Schuler

- Sub-Investigator in Phase-2-study „Candesartan in Heart Failure” (TAKEDA Study No. TCV-116/EC605),

- Phase-3 studies: Carvedilol or Metoprolol European Trial (COMET),

- Levosimendan Infusion versus Dobutamine (LIDO) trial,

- Effects of eniporide in acute myocardial infarction (ESCAMI) trial,

- Blockade of the glycoprotein IIb/IIIa receptor to avoid vascular occlusion (BRAVO) trial,

- Orbofiban in Patients With Unstable Coronary Syndrome (OPUS) trial.



Professional Achievements

27.07.2022 Associate Professor (außerplanmäßiger Professor) at Martin-Luther-University Halle-Wittenberg, Medical Faculty, proof: https://www.campus-halensis.de/site/assets/files/214642/scientia_web.pdf

11.04.2018 Approval for SpecialtyTransplantation medicine“ (designation issued by Landesärztekammer Sachsen-Anhalt“, administrative body for medical affairs in the German federal state of Sachsen – Anhalt)

15.11.2016 PhD equivalent „Habilitation“ (Dr. habil.), Topic: „Neurohumoral Stimulation as Disease mechanism in nephrogenic arterial Hypertension and chronic heart failure“

Proof: Dtsch Arztebl 2017; 114(16): A-801 / B-677 / C-663

15.11.2016 Designation “Privatdozent(issued by Martin-Luther University Halle-Wittenberg) for proven ability to teach Internal- Medicine lectures, seminars).

22.09.2016 Fellow of American Society of Nephrology (FASN)

29.06.2016 Approval for SpecialtyDiabetology“ (designation „Zusatzbezeichnung“ issued by „Landesärztekammer Sachsen-Anhalt“, administrative body for medical affairs in the German federal state of Sachsen-Anhalt)

20.02.2008 Approval for Specialty „Nephrology“

(designation „Subspezialisierung“ issued by „Landesärztekammer Hessen“, administrative body for medical affairs in the German federal state of Hessia)

08.06.2006 Approval for Specialty „Internal Medicine“ ((designation „Facharzt“ issued by „Landesärztekammer Sachsen“, administrative body for medical affairs in the German federal state of Saxony)

Nov 2000 Doctoral Thesis (MD Thesis, designation issued by University of Leipzig: „doctor medicinae“): Topic: “Cardiovascular effects mediated by estrogen in postmenonpausal wormen with cardiac syndrome X“, Advisor: Prof. Rainer J. Zotz.



Education, Military and Civic Service, Residency

Apr 1997 - Sep 1998 Residency („Arzt im Praktikum“) in Department of Cardiology, Heart Centre Leipzig, Head: Prof. Dr. Gerhard Schuler

Oct 1990 - Mar 1997 Medical Studies at University of Leipzig, Germany.

4 months of the 6th year (1996), Medical Studies, at University of Nancy, Department of Cardiology, Intermediate Care, Nancy, France.

May 1990 – Sep 1990 Civic Service at St. Georg“ Hospital, Leipzig, Germany

Nov 1989 – Apr 1990 Military Service („NVA“ Army of former GDR, „Mot.-Schützen-Regiment 2“, Stahnsdorf, GDR)

Sep 1989 - Oct 1990 Pre-study Practical Training at District Hospital „St. Georg“, Leipzig, GDR.

Sep 1987 - Aug 1989 School: 11th and 12th grade at Specialized High Scool (“Erweiterte Oberschule Karl Marx“) in Leipzig, GDR

Sep 1977 – Aug 1987 School: 10 grades of combined primary and high School („Polytechnische Oberschule Hans und Hilde Coppi“) in Leipzig, GDR



Grants, Awards

2008: Research Prize of „Deutsche Nierenstiftung“ (€ 25,000), Project: “Sympathetic nervous system activation in nephrogenic hypertension“)

2007: Aventis Research Grant (€ 25,000): Project: “Sympathovagal balance and Rho-kinase activity in models of renal arterial hypertension with high versus low plasma angiotensin: therapeutic implications.”

2004: Ernst und Berta Grimmke - Stiftung (€ 10,000), Project: “Cardiovascular Pathomechanisms in chronic kidney disease“.

Apr – Oct 2003 Ministry for Education and Research (Bundesministerium für Bildung und Forschung) – Sabbatical (ongoing salary) during work on Project: „V2-Vasopressin-receptor deficient mice as pathophysiological and therapeutic model for nephrogenic diabetes insipidus“

Jul – Dec 2001 American Heart Association, Postdoctoral Fellowship Award ($ 78,000), Project: “Statin Effects on Autonomic Neural Control in Heart Failure - A Proposed Nonlipidemic Mechanism.”

May 2001 Best-Poster-Award Finalist, Nebraska-Physiological Society, Omaha, Nebraska, USA

Apr 2001 NCAR Brody-Award Finalist, Meeting of Experimental Biology, Orlando, Florida, USA

Oct 2000 Young Investigators Conference on Atherosclerosis Award, Merck & Co., Inc., Rahway, New Jersey, USA



Membership in Professional Societies

European Society of Study of Diabetes (EASD), German Diabetes Society (DDG), German Society of Nephrology (DGFN). American Physiology Society (APS), American Society of Nephrology (ASN)

2016 - 2018 Diabetes Society of Sachsen-Anhalt (member of body of governance)



Research projects

(ongoing ones)

- Role of continuous glucose monitoring in non-insulin dependent diabetes, type2, and prediabetes (advisor of MD thesis by C. Rädel)

- Use of arteficial intelligence for the detection of diabetes patients at risk for hypogycemia

- Use of arteficial intelligence for detection of chronic kidney disease patients with diabetes at risk for hyoglycemia



(finished ones)

2017 – 2020 Prevalence of Incretin-Mimetic and Sodium-Glucose-Transporter-2-Inhibitor Therapy in German Hospitalized Type-2 Diabetics Following Myocardial Revascularization: An Observational Study (advisor for MD thesis by Linda Golle)

2017 – 2020 Glycopenia and Hypertension (advisor for MD thesis by Abimbola Abobarin-Adeagbo)

2013 - 2018: Hyponatremia in cardiorenal syndrome: retrospective observational study (advisor for MD thesis by Katrin Schlump)

2012 – 2018: Monocyte function in decompensated cardiorenal syndrome, type 1 and 3, Ronco classification (advisor for MD thesis by Christoph Linhart)

2007 – 2015 Oral supplemental nutrition in end-stage renal disease with and without HIV Comorbidity (advisor for MD thesis by Michael Zilles)

2007 – 2009 Sympathoactivation in models of nephrogenic hypertension (Vascular research centre, Head: Prof. Dr. Ralf P. Brandes)

2002 – 2006 Hormonal effects on hunger and satiety, a fMRI study (cooperation between Department of Endocrinology/Diabetology of University of Leipizig and Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig)

2002 – 2006 Role for Sympathoactivation in Insulin Resistance in Type-2 Diabetes, a microneurography study (investigator-initiated study, in preparation)

1999 – 2001 Role of Statins (beta-HMG-CoA-reductase inhibitors) on sympathetic tone in chronic heart failure (investigator-initiated animal study)

1999 – 2001 Role of Exercise on sympathetic tone in chronic heart failure (Project devoloped by Prof. Irving H. Zucker)



Extra-curricular Activities

- 2016-2018: Head and Founder of Task Force “Healthy Nutrition in Hospital“ at University Hospital Halle

News Coverage in Newspapers, and TV (u.a. „ARD-Mittagsmagazin on 31.1.2018“)

- 14th Nov 2019: Organizer of Public Presentations on behalf of World-Diabetes-Day in Cottbus, Germany

- 4th Feb 2020: „Frontal 21“ TV coverage (Interview) on JAMA publication on artificial sweeteners

- 14th Nov 2020: Organizer of Public Presentations on behalf of World-Diabetes-Day in Cottbus, Germany

- 14th Nov 2021: Organizer of Public Presentations on behalf of World-Diabetes-Day in Cottbus, Germany

- 2022: Guest Editor of Special Issue (part 1) „New Advances in Cardiorenal Syndrome, finished issue published by Journal of Clinical Medicine (MDPI, Basel, Sitzerland) under

https://www.mdpi.com/journal/jcm/special_issues/Advances_Cardiorenal_Syndrome

- 2024: Guest Editor of Special Issue (part 2) „New Advances in Cardiorenal Syndrome, Outline of planned papers (following peer review) under

https://www.mdpi.com/journal/jcm/special_issues/P8V895GKE0

- 2024: Founding member (Dres. H.K. Maerz and R.U. Pliquett) of Insitute for Applied Information Technologies in Medicine

www.iaitmed.de

www.techmedinstitute.com



Advisory Boards

Ministry of Health of German Federal State Brandenburg (2019),

Boehringer-Ingelheim (since 2016)



Speaker Activities

- March 2024: Diabetes Refresher (Online, 1 tutorial à 45 min), chaired by Prof. Dr. P. Schwarz (Univ. Dresden)

- March 2024: 102. DDG Diabetologie Fachkunde-Kurs (Online, 3 tutorials à 45 min), chaired by Prof. Dr. P. Schwarz (Univ. Dresden)

- 1st Dec 2023: „Hypertonie-Kongress“ der Deutschen Hypertonie Liga at Berlin (presentation), topic: „Hochdruck & Niere – glomeruläre Filtration unter Druck“, Full Programm: https://www.hypertoniekongress.de/programm2023/

- 30th Nov 2022: „Digitales Forum Herz und Hiere“ (online), topic: „Der kardiorenale Patient aus Sicht des Nephrologen – Kaliummanagement“

- 12th Nov 2022: 3. „Internistenforum in Halle“ at Mühlenhotel Halle Leipzig (presentation), topic: „Leitlinien Update bei kardiorenalen Patienten“

- 4th Nov 2022: 28. „Dresdner Symposium“ at Ramada by Wyndham Hotel, Dresden (presentation), topic: „Herz und Niere – Die Sicht der Nephrologen“

- 16th Mar 2022: Meeting on New Methods in Diagnostics and Therapy by Medizinische Gesellschaft Ost-Brandenburg (presentation), topic: „Kontinuierliche Glukosemessung – Was bringt es?“

- 10th Oct 2021: Anual national meetings of Deutsche Gesellschaft für Innere Medizin at Göttingen (online), topic: „Best-Practice" Weiterbildung: Kliniken stellen ihr Erfolgsrezept vor“, full presentation: https://www.researchgate.net/publication/355169197_Best-Practice_Weiterbildung_Kliniken_stellen_ihr_Erfolgsrezept_vor

- 29th Apr 2017: Annual Diabetes Workshop at Zingst (presentation), topic: Chronische Herzinsuffizienz und Typ-2-Diabetes – was gibt es zu beachten?

- 16th Jun 2016: „6. Brandenburger Nephrologie Kolleg“ of BBNK (presentation), topic: „Lohnt sich eine orale Ernährungstherapie?“, full presentation: https://slideplayer.org/slide/11819916/

- 22th Nov 2015: CME sponsored by AbbVie Deutschland at Überörtliche Berufsausübungsgemeinschaft Dres. Schumann/Knevels/Hoffmann&Kollegen, Lünen (presentation), topic: „Modernes sHPT Management und der Stellenwert der alkalischen Phosphatase“

- 25th Apr 2015: „Forum Schmerz 2016 – Schmerztherapie im Dialog at Magdeburg (presentation), topic: „Schmerztherapie bei Niereninsuffizienz – was gibt es zu beachten“

- 18th Oct 2012: „14. Nephrologie-Aktuell“ at Dorint Charlottenhof Hotel, Halle (Saale) (presentation), topic: „Behandlungsoptionen bei cardiorenalem Syndrom“



Chair of Symposia Sessions and Scientific Meetings

- 16th Nov 2013: Annual Meeting of „Innere Medizin Sachsen-Anhalt, IMSA“ at Ringhotel Schloss Schkopau, Schkopau, Session „Sitzung III, Interdisziplinäre Probleme“

- 13th May 2016: „1. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Halle (Saale), Germany

- 12th May 2017: „2. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Halle (Saale), Germany (intermission – piano music by Jan-Christoph Homann: Liszt, Chopin, Rachmaninov)

- 4th May 2018: „3. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Halle (Saale), Germany

- 31st Aug 2018: 14. Nationales Treffen Netzwerke Diabetischer Fuß“ (ca. 400 Diabetologists, Diabetes Nurses, Family Physicians) at Halle (Saale), Germany

- 10th May 2019: „4. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Cottbus, Germany

- 23rd Nov 2019: 19. Herz-und-Nierentag“ in Cottbus (ca. 70 Cardiologists, Nephrologists, Family Physicians)

- 8th May 2020: „5. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Cottbus, Germany

- 7th May 2021: „6. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Cottbus, Germany

- 21st May 2022: „7. Mering-Symposium für Diabetes-Technologie und Prävention“ (ca. 100 Diabetologists, Diabetes Nurses, Family Physicians) at Cottbus, Germany, (intermission Pop and Jazz classics by singer Polina Shkodiviska)



Publishing Activities

46 publications listed in Pubmed.gov (as of 24th Feburary 2024)

5 latest publications:

Abobarin-Adeagbo A, Kraya T, Girndt M, Pliquett RU, Correction of Over-Dosed Insulin in a Type-2- Diabetic Led to a Better Control of Glycemia and Arterial Hypertension: A Case Report. Journal of Pharmacy and Pharmacology Research. 2023;7: 227



Pliquett RU. New Advances in Cardiorenal Syndrome-Ready for Prime Time? J Clin Med. 2022 ;11:3460



Pliquett RU. Cardiorenal Syndrome: An Updated Classification Based on Clinical Hallmarks. J Clin Med. 2022;11:2896



Mammadova N, Soukup J, Shkodivskyi P, Gudowski C, Ahmed A, Pliquett RU. A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report. BMC Nephrol. 2022;23:174



Pliquett RU, Brandes RP. Experimental uninephrectomy associates with less parasympathetic modulation of heart rate and facilitates sodium-dependent arterial hypertension. PLoS One. 2022;17:e0265086



Leipzig, 26th March 2024





Prof. Dr. Rainer U. Pliquett